My research interests
My primary research interests are in the area of biological modeling.
Over the last few years, my colleagues and I have developed a
physiologically-based model of the aortic baroreceptor neuron using rat
data from our labs and from the literature. This model employs three
stages: a viscoelastic arterial
wall represented by coupled springs and dashpots; a Hodgkin-Huxley-type
transducer membrane which transduces wall strain to a generator potential
via a mechanosensitive channel; and a Hodgkin-Huxley-type model of the spike
initiation zone at the first node of Ranvier. We are currently utilizing
this model to analyze and predict ionic mechanisms responsible for the
nonlinear behavior observed in the baroreceptor, including post-excitatory
depression and hysteresis. A recent
abstract summarizes some of our
I have developed an interest in the analytical tools used to interpret
signal data, including Fourier analysis and describing function methods. I am
fascinated by nonlinearity and chaos and the techniques used to study them.
I have dabbled in optimization, but have had only limited success in applying
such techniques to the high-order nonlinear models developed by our group.
Recently, in addition to my continuing work with the baroreceptor model, I
have been involved with developing a model of the rat heart and near systemic
circulation, as well as a model of human metabolism.
Last modified: 14 Jan 2001